Sökning: "platelet-activating factor PAF"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden platelet-activating factor PAF.

1. 16. Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease

   Författare :Anna Cederholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Systemic lupus erythematosus; cardiovascular disease; atherosclerosis; atherothrombosis; antiphospholipid antibodies; Annexin A5;

   Sammanfattning : Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The etiopathigenesis of SLE remains incompletely understood. LÄS MER

3. 17. Lipids and autoimmunity in atherosclerosis and cardiovascular diseases

   Författare :Xiang Hua; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Atherosclerosis is an inflammatory disease. The rupture of athrerosclerotic plaques is the major cause of severe cardiovascular disease (CVD), such as myocardial infarction (MI) and stroke. The stability of the plaque depends on its cellular and extracellular contents. LÄS MER

4. 18. Acute lung failure induced by tricyclic antidepressants : an experimental evaluation

   Författare :Karin Svens; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ARDS; tricyclic antidepressants; isolated lungs; rat; endothelin; endothelial cells; tight junctions;

   Sammanfattning : The tricyclic antidepressant drugs (TCA) have, over the years, been reported to be able to cause adult respiratory distress syndrome (ARDS)/acute lung injury in connection with overdose, and are currently among the most common cause of self-poisoning. Approximately 10% of all TCA overdose patients develop ARDS, and the treatment of these patients, irrespective of the event causing ARDS, is mainly supportive. LÄS MER

5. 19. Studies on the structure, function and expression of phospholipase A2

   Författare :Pontus Larsson Forsell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Phospholipase A2 (PLA2) enzymes are widely distributed and the enzymes possess different functions such as a role in digestion and inflammation. PLA2 catalyzes the hydrolysis of the sn-2 acylester bond of phospholipids, yielding a free fatty acid and a lysophospholipid. LÄS MER

7. 20. Tissue kallikrein: pathophysiological role in acute pancreatitis

   Författare :Mats Bläckberg; Helsingborg Kliniska Vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute pancreatitis; aprotinin; alpha-macroglobulin; alpha1-proteinase inhibitor; turn over; kinin B2 receptor; kallidin; bradykinin; Tissue kallikrein; kallistatin; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. LÄS MER