Sökning: "aprotinin"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet aprotinin.

  1. 1. Tissue kallikrein: pathophysiological role in acute pancreatitis

    Författare :Mats Bläckberg; Helsingborg Kliniska Vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute pancreatitis; aprotinin; alpha-macroglobulin; alpha1-proteinase inhibitor; turn over; kinin B2 receptor; kallidin; bradykinin; Tissue kallikrein; kallistatin; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. LÄS MER

  3. 2. Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

    Författare :Erika Spens; Lena Häggström; Jean-Louis Goergen; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NS0 myeloma cells; protein-free medium; fed-batch; conditioned medium; autocrine growth factors; abortive proliferation; protease activity; aprotinin; gp130; Bioengineering; Bioteknik;

    Sammanfattning : The overall objective of this study was to investigate how NS0 cell proliferation is regulated in protein-free media. The hypothesis was that during the adaptation to growth factor-free media, animal cell lines start to produce their own autocrine growth factors to support proliferation, and after some time in a culture the effects of these factors are lost which results in cessation of proliferation. LÄS MER

  4. 3. Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery

    Författare :Gabriella Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute coronary syndrome; aprotinin; clopidogrel; platelets; surgery; tranexamic acid; transfusions;

    Sammanfattning : Background: An increased proportion of patients with acute coronary syndrome undergo coronary surgery while treated with clopidogrel, an irreversible platelet ADP-receptor inhibitor. Clopidogrel in combination with aspirin is known to augment bleeding, transfusion requirements, and reoperation rates after coronary surgery. LÄS MER

  5. 4. Coagulation during and after cardiopulmonary bypass with focus on heparin, protamine, aprotinin and platelet function

    Författare :Gunilla Kjellberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heparin and protamine dosing for anticoagulation during cardiopulmonary bypass (CPB) and its reversal after CPB, respectively, is usually given according to body weight. Excess protamine may impair coagulation. The HeProCalc algorithm calculates heparin and protamine doses during the procedure. LÄS MER

  7. 5. Cardiac surgery and antiplatelet therapy

    Författare :Carl Johan Malm; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac surgery; Platelets;

    Sammanfattning : Background Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and a P2Y12 inhibitor improves outcome in acute coronary syndrome (ACS). In the subset of ACS patients undergoing urgent cardiac surgery, ongoing or recently discontinued DAPT is associated with increased risk of bleeding. LÄS MER