Sökning: "platelet stimulation"

Visar resultat 6 - 10 av 70 avhandlingar innehållade orden platelet stimulation.

  1. 6. Mechanisms of platelet-mediated fibroblast proliferation

    Författare :Cecilia Berg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Wound healing is a multicomponent event that involves a network of molecular and cellular crosstalk between cells, including leukocytes, platelets and fibroblasts. Despite increased knowledge over the past decades regarding the regulation of cell and tissue growth, the inter- and intracellular systems that control wound healing are incompletely understood. LÄS MER

  3. 7. Platelet function in polycythemia vera : studies of agonist and cytokine induced platelet activation

    Författare :Katarina Le Blanc; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycythemia vera (PV) is a malignant myeloproliferative disorder characterized by an increased red cell mass and most often accompanied by leukocytosis and thrombocytosis. The pathogenic mechanisms behind PV are still largely unknown. LÄS MER

  4. 8. Effects of high glucose on platelet activation

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; Karolinska institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular mortality and morbidity, due to diabetic angiopathy. Hyperglycaemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated the mechanisms underlying hyperglycaemia-induced platelet hyperreactivity and its impact in diabetic patients. LÄS MER

  5. 9. Platelet-derived growth factor-induced signal transduction

    Författare :Sigrídur Valgeirsdóttir; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER

  7. 10. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

    Författare :Karina Åhlén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. LÄS MER