Sökning: "platelet stimulation"

Visar resultat 16 - 20 av 70 avhandlingar innehållade orden platelet stimulation.

  1. 16. Platelet function in diabetes mellitus : relationships to hyperglycaemia, antidiabetic treatment and microangiopathy

    Författare :Marianne Yngen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Diabetes mellitus; platelet function; P-selectin; leukocyte-platelet cross-talk; endothelium; inflammation; coagulation; hyperglycaemia; metabolic control; microvascular complications; percutaneous coronary intervention.;

    Sammanfattning : Diabetes mellitus is associated with accelerated atherosclerosis and increased morbidity and mortality in micro-and macrovascular complications. The metabolic derangements that accompany diabetes can adversely influence platelets and vascular endothelial function, which may contribute to the pathogenesis of diabetic angiopathy. LÄS MER

  3. 17. Platelet angiogenic activities and their regulation on endothelial progenitor cell functions

    Författare :Zhangsen Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which contribute importantly to vascular regeneration and endothelium reparation. LÄS MER

  4. 18. Studies of platelet function, and effects of aspirin and clopidogrel treatment

    Författare :Christina Perneby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antiplatelet therapy with aspirin and clopidogrel is a cornerstone in cardiovascular prevention and lowers cardiovascular mortality and morbidity in patient with coronary artery disease (CAD). Mental stress and physical exertion can trigger acute coronary events and prothrombotic responses to stress may contribute to such triggering. LÄS MER

  5. 19. Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated mechanisms underlying hyperglycemia-induced platelet dysfunction, and its impact in DM patients. LÄS MER

  7. 20. Platelet and leukocyte activation and their interaction : in experimental prothrombotic and inflammatory states

    Författare :Nailin Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerotic disease is associated with inflammation and thrombosis, both of which involve multi-cellular activation and interaction. The present work has investigated the mechanisms of platelet leukocyte cross-talk in vitro, and explored the possibility of multi-cellular activation in vivo in prothrombotic and inflammatory models in healthy volunteers. LÄS MER