Sökning: "plasma separation"

Visar resultat 31 - 35 av 125 avhandlingar innehållade orden plasma separation.

  1. 31. Proteomics of neurodegenerative diseases using novel online isoelectric point separation

    Författare :Mohammad Pirmoradian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The work presented in this thesis describes an instrument, developed for separation of proteins and peptides based on corresponding isoelectric point (pI) values, to empower mass spectrometry-based proteomics analysis. The main objectives are the instrument development and optimization, as well as clinical applications in biomarker discovery, particularly for neurodegenerative disorders. LÄS MER

  3. 32. Fat contamination of pericardial suction blood in cardiac surgery : clinical and experimental studies in perspectives of transfusion logistics

    Författare :Micael Appelblad; Gunnar Engström; Krister Lindmark; Anders Jeppsson; Umeå universitet; []
    Nyckelord :Surgery; blood transfusion; cardiopulmonary bypass; pericardial suction blood; fat contamination; lipid microemboli; density separation; surface adsorption; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Introduction: During cardiac surgery aided by cardiopulmonary bypass (CPB) the autotransfusion of pericardial suction blood (PSB) is regarded mandatory to limit allogeneic blood exposure. PSB is however proposed as a source of lipid microemboli and to contribute to brain damage. LÄS MER

  4. 33. From achiral to chiral analysis of citalopram

    Författare :Björn Carlsson; Yngve Bergqvist; Linköpings universitet; []
    Nyckelord :depression; noradrenaline; dopamine; serotonin; citalopram; selective serotonin-reuptake inhibitor SSRI ; high-performance liquid chromatography HPLC ; therapeutic drug monitoring TDM ; enantioselective separation; MEDICINE; MEDICIN;

    Sammanfattning : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. LÄS MER

  5. 34. Determination of the Environmental Fate of Drug Substances and the Matrix Effects of Complex Samples in SFC/ESI-MS

    Författare :Alfred Haglind; Curt Pettersson; Mikael Hedeland; Torbjörn Arvidsson; Deirdre Cabooter; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SFC-MS; matrix effect; ion cluster; Supercritical fluid chromatography; ESI; chiral separation; transformation products; LC-QToF; wetland microcosms; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds. LÄS MER

  7. 35. Experimental gene therapy with special reference to plasma cell tumors

    Författare :M Sirac Dilber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene therapy may open new perspectives in the treatment of numerous hematopoietic and metabolic disorders. Particularly, hematopoietic cells are very attractive targets for retroviral mediated gene transfer. LÄS MER