Sökning: "nucleotide receptors"

Visar resultat 31 - 35 av 46 avhandlingar innehållade orden nucleotide receptors.

  1. 31. The human pancreatic polypeptide receptor Y4 : Genetic and functional variation

    Författare :Kateryna Shebanits; Dan Larhammar; Sadaf Farooqi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NPY4R; Y4; obesity; CNV; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Humans are evolutionarily adapted to an environment where food is scarce, but today many live in a world of food abundance. Paired with low physical activity, this may lead to weight gain and obesity. Efficient anti-obesity treatments require understanding of the mechanisms that control hunger, satiety, energy metabolism and body weight. LÄS MER

  3. 32. DNA repair pathways and the effect of radiotherapy in breast cancer

    Författare :Karin Söderlund Leifler; Marie Askmalm Stenmark; Olle Stål; Bo Stenerlöw; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : A large proportion of breast cancer patients are treated with radiotherapy. Ionising radiation induces different DNA damages, of which double-strand breaks are the most severe. They are mainly repaired by homologous recombination or non-homologous end-joining. Different protein complexes have central roles in these repair processes. LÄS MER

  4. 33. The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury

    Författare :Maria Hammarlund; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha 7 nicotinic acetylcholine receptor; inflammation; brain injury; CHRNA7; CHRFAM7A; stroke; hypoxia ischemia; neonatal encephalopathy; human; PBMC;

    Sammanfattning : The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common component in the pathology of many diseases and injuries, including brain damage. LÄS MER

  5. 34. Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7

    Författare :Henrik Jörnvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transforming growth factor beta (TGFbeta) superfamily of polypeptide growth factors encompasses more than 30 diverse mammalian members. They are involved in most cellular processes, ranging from cell proliferation and differentiation, to survival and death. Loss of TGFbeta activity is coupled to tumor development and many other disorders. LÄS MER

  7. 35. Steroid metabolism in human reproductive organs

    Författare :Anna Helena Karypidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Androgens are involved in the development of prostate cancer. Both UGT2B17 and CYP7B1 are involved in the metabolism of androgens and are highly abundant in the prostate. Deletion of the UGT2B17 gene is associated with low or undetectable urinary testosterone levels. LÄS MER