Sökning: "nucleotide receptors"

Visar resultat 11 - 15 av 46 avhandlingar innehållade orden nucleotide receptors.

  1. 11. Array based genetic profiling of chronic lymphocytic leukemia

    Författare :Rebeqa Gunnarsson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prognostic markers; copy-number neutral loss of heterozygosity; copy-number aberrations; chronic lymphocytic leukemia; genomic microarrays; clonal evolution; stereotyped B-cell receptors;

    Sammanfattning : Although no common genetic defect has been described in chronic lymphocytic leukemia (CLL), recurrent genomic aberrations (i.e. deletions of chromosome 11q, 13q, 17p and trisomy 12) are important for prognostication. Deletion of 13q as single aberration is associated with the best prognosis, whereas del(11q) and del(17p) predict a poor outcome. LÄS MER

  3. 12. Molecular genetic studies of psoriasis susceptibility in 6p21.3

    Författare :Sofia Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Complex disease; genetic; Psoriasis Susceptibility region 1 PSORS1 ; human leukocyte antigen C HLA-C ; linkage disequilibrium; major histocompatibility complex; single nucleotide polymorphism;

    Sammanfattning : Psoriasis is a common and chronic skin disease with multifactorial background. It affects approximately 2% of the Swedish population and is characterized by inflammatory and scaly lesions. The aetiology of psoriasis is not yet known, however, the genetic contribution to the disease is strong. LÄS MER

  4. 13. 5-HT2A : a serotonin receptor with a possible role in joint diseases

    Författare :Anders Kling; Solbritt Rantapää-Dahlqvist; Carl-Olav Stiller; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 5-HT2A serotonin receptor; serotonin; rheumatoid arthritis; adverse drug reaction; HTR2A; glucocorticoids; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : BackgroundSerotonin (5-HT), an amino acid derivative and neurotransmitter, has for long been studied in relation to inflammation. It is an endogenous ligand for several different types of serotonin receptors. The serotonin receptor 5-HT2A has been reported to have a role in the pathophysiology of arthritis in animal experiment models. LÄS MER

  5. 14. Nasal epithelial cells : innate immunity and inflammation

    Författare :Lotta Tengroth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The surface epithelium that lines the nasal passages is often the first tissue in the airway to encounter inhaled pathogens. It collaborates closely with the innate immune system, a subsystem of the immune system that defends the host from infection by organisms, mainly by initiating a local inflammatory reaction. LÄS MER

  7. 15. Local Purinergic Control of Arteriolar Reactivity in Pancreatic Islets and Renal Glomeruli

    Författare :Xiang Gao; Leif Jansson; Olle Hellberg; Uppsala universitet; []
    Nyckelord :afferent arteriole; islet arteriole; adenosine; A1 receptor; ATP; P2Y receptor; microperfusion; angiotensin II; type 2 diabetes; hypertension; oxidative stress; nitric oxide; tubuloglomerular feedback;

    Sammanfattning : Local control of regional blood flow is exerted mainly through the arterioles. An adequate minute-to-minute regulation of blood perfusion of the kidney and the pancreas is obtained by the modulation of arteriolar reactivity, which will influence the organ function. LÄS MER