Sökning: "myelin basic protein"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden myelin basic protein.

1. 16. Modulation of experimental T cell autoimmunity in the nervous system with emphasis on nasal tolerance

   Författare :Xue-Feng Bai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Experimental autoimmune neuritis (EAN) and encephalomyelitis (EAE) are animal models of Guillian-Barre syndrome (GBS) and multiple sclerosis (MS), representing human demyelinating diseases of the peripheral nervous system (PNS) and central nervous system (CNS), respectively. CD4+ T cells recognizing myelin antigens and producing cytokines play central roles in the pathogenesis of both EAN and EAE and perhaps of GBS and MS. LÄS MER

3. 17. Mechanisms and modulation of experimental allergic encephalomyelitis as basis for treatment of multiple sclerosis

   Författare :Ling-Yun Xu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Its etiology is unknown and there exists no cure. LÄS MER

4. 18. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

   Författare :Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

   Sammanfattning : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. LÄS MER

5. 19. Neurotrophic and immune regulatory factors in neuroinflammation

   Författare :Alexander W Gielen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurotrophins; EAE; MS; TIM; Neuroprotection;

   Sammanfattning : Inflammatory reactions in the nervous system act as a double-edged sword. On the one hand, neuroinflammation can have very devastating effects on the nervous system, leading to neurological dysfunction. LÄS MER

7. 20. Studies on dendritic cells in multiple sclerosis and experimental allergic encephalomyelitis

   Författare :Yu-Min Huang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination, axonal loss and, ultimately, formation of gliotic scar tissue in the brain and spinal cord. MS remains the major disabling neurological illness of young adults of North European origin. LÄS MER