Sökning: "mucosal barrier integrity"

Visar resultat 11 - 15 av 15 avhandlingar innehållade orden mucosal barrier integrity.

  1. 11. Factors associated with HIV susceptibility in the female genital tract

    Författare :Frideborg Bradley; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The majority of new HIV infections in women are transmitted through vaginal intercourse where the female genital tract (FGT) functions as the portal of viral entry. The aim of this thesis was to characterize mucosal factors within the FGT to better understand potential molecular mechanisms associated with altered HIV-susceptibility. LÄS MER

  3. 12. HIV susceptibility factors in the human genital mucosa

    Författare :Maria Röhl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Heterosexual HIV transmission is the most common viral transmission route worldwide. To establish a persistent infection the virus needs to cross the mucosal surface of the genital tract. The genital mucosa is thus considered to be the portal of HIV entry and initial site of viral replication. LÄS MER

  4. 13. Exploring probiotics-host interactions : intestinal immune and defence responses to Lactobacillus reuteri in health and disease

    Författare :Shokoufeh Karimi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Lactobacillus reuteri, a ubiquitous inhabitant of the mammalian gastrointestinal (GI) tract has known health-promoting effects and various strains are commercially available as probiotics. Several probiosis mechanisms have been suggested in L. reuteri’s mode of action, but the mediators and factors involved are not well understood. LÄS MER

  5. 14. Gut derived chronic inflammation in HIV-1 and chronic kidney disease : the role of the microbial metabolite TMAO and immunomodulatory effects of Vitamin D

    Författare :Catharina Missailidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Persistent immune activation with premature ageing and increased risk of cardiovascular disease (CVD) are features shared by HIV-1 infected individuals and patients with chronic kidney disease (CKD). Underlying dysbiosis, a failing mucosal barrier function and microbial translocation (MT) are contributing factors in both conditions. LÄS MER

  7. 15. In situ characterization of immune cells mediating potential control of HIV infection in the female genital mucosa

    Författare :Anna Gibbs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Heterosexual HIV transmission is the most common viral transmission route, worldwide, where young women are more susceptible to HIV infection than men. To establish a persistent infection the virus needs to cross the mucosal surface of the female genital tract (FGT). LÄS MER