Sökning: "motor phenotype"

Visar resultat 11 - 15 av 67 avhandlingar innehållade orden motor phenotype.

  1. 11. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease

    Författare :Rana Soylu Kucharz; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s Disease; Huntingtin; Hypothalamus; Metabolism; Obesity; orexin; PVN; BAT; TH; neuroendocrinology;

    Sammanfattning : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. LÄS MER

  3. 12. Crossing the Midline : Locomotor Neuronal Circuitry Formation

    Författare :Fatima Memic; Klas Kullander; Avihu Klar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CPG; CIN; neuronal network; locomotion; left-right alternation;

    Sammanfattning : Networks at various levels of the nervous system coordinate different motor patterns such as respiration, eye or hand movements and locomotion. Intrinsic rhythm-generating networks that are located in the spinal cord generate motor behaviors that underlie locomotion in vertebrates. LÄS MER

  4. 13. Progenitor cells in the brainstem and filum terminale

    Författare :Michael Fagerlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :brainstem;

    Sammanfattning : Neurogenesis prevails in the adult mammalian CNS. New neurons are constitutively formed invivo in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone of the dentate gyrus. LÄS MER

  5. 14. Diving into the zebrafish locomotor network : A study on dI6 interneurons

    Författare :Ana Belen Iglesias Gonzalez; Henrik Boije; Filippo Del Bene; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; danio rerio; locomotion; dmrt3a; wt1a; calretinin; transcriptome; spinal cord; morphology; dI6 neurons; knock-down out; Neuroscience; Neurovetenskap;

    Sammanfattning : The generation and coordination of locomotion comprise of inhibitory and excitatory interneurons that govern motor neuron output to muscles. This neuronal network is known as the central pattern generator (CPG). Spinal inhibitory interneurons that originate from the dI6 population play a crucial role in the coordination of locomotor output. LÄS MER

  7. 15. Functional brain imaging of sensorimotor dysfunction and restoration : investigations of discomplete spinal cord injury and deep brain stimulation for essential tremor

    Författare :Amar Awad; Johan Eriksson; Patric Blomstedt; Richard Levi; Lars Nyberg; Rick Helmich; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sensorimotor control; fMRI; discomplete spinal cord injury; essential tremor; deep brain stimulation; cerebello-thalamo-cerebral circuit; Physiology; fysiologi; neurokirurgi; Neurosurgery; Neurology; neurologi; rehabiliteringsmedicin; Rehabilitation Medicine;

    Sammanfattning : The nervous system exists to generate adaptive behaviour by processing sensory input from the body and the environment in order to produce appropriate motor output, and vice versa. Consequently, sensorimotor dysfunction is the basis of disability in most neurological pathologies. LÄS MER