Sökning: "mitotic aberrations"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden mitotic aberrations.

  1. 6. Prognosis based classification and tumor biology of uterine sarcomas

    Författare :Elin Hardell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Uterine stromal sarcomas are a heterogenous group of tumors ranging from low-grade stromal sarcomas with a relatively good survival but high risk of recurrence, to undifferentiated uterine sarcomas with a far worse prognosis. Little is known about their biology, and prognostic markers are lacking. LÄS MER

  3. 7. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma

    Författare :Bettina Gruhne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. LÄS MER

  4. 8. Mechanisms and Consequences of Chromosomal Instability in Malignant tumours

    Författare :Ylva Stewénius; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; structural rearrangement; Ewing family tumour; Chromosomal instability; nephroblastoma; Wilms tumour; chromosomal aberration; anaphase bridge; subtelomeric FISH; breakage-fusion-bridge cycle;

    Sammanfattning : In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. LÄS MER

  5. 9. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome

    Författare :Cecilia Nilsson; Marie-Louise Fjällskog; Leif Bergkvist; Thomas Hatschek; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male breast cancer; immunohistochemistry; prognostic; cyclins; gene expression; genomic profiling; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. LÄS MER

  7. 10. Regulation of apoptosis during treatment and resistance development in tumour cells

    Författare :Jeanette Blomberg; Erik Lundgren; John Eriksson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumörbiologi; Tumour biology; Tumörbiologi;

    Sammanfattning : Induction of apoptosis is the most studied cell death process and it is a tightly regulated physiological event that enables elimination of damaged and unwanted cells. Apoptosis can be induced via activation of either the intrinsic or the extrinsic signalling pathway. LÄS MER