Sökning: "memantine"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet memantine.

  1. 6. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

    Författare :Christina Unger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

    Sammanfattning : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. LÄS MER

  3. 7. Health inequalities in care for persons with dementia

    Författare :Minh Tuan Hoang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Health inequality is defined as any difference, disparity, or variation in all health-related aspects of individuals and groups. The World Health Organization regards ensuring equal access to promotion, prevention, diagnostics, and care for persons with dementia as a crucial goal in their global action plan for dementia. LÄS MER

  4. 8. Dementia management in European primary care

    Författare :Ferdinando Petrazzuoli; Allmänmedicin och samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dementia; mild cognitive impairment; Grounded Theory; Demens; lindrig kognitiv svikt; grundad teori;

    Sammanfattning : Background: Around 50 million people worldwide have dementia and the prevalence is expected to increase to 152 million by 2050. According to the WHO, dementia is a priority health policy issue. LÄS MER

  5. 9. Diabetes mellitus in patients with dementia : clinical care and pharmacological treatment

    Författare :Juraj Sečník; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) and dementia are frequent chronic disorders in the older population, however their relationship is complex - while DM is an established risk factor for dementia, cognitive symptoms in dementia may hinder the self-management essential in DM care. Importantly, the co-occurrence of DM and dementia is common in clinical practice, however the research examining patients suffering from both disorders is scarce. LÄS MER

  7. 10. Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer's disease-related mouse models : interactive mechanisms with focus on new drug targets

    Författare :Monika M Hedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Accumulation of beta-amyloid (Abeta), neuronal loss and changes in neurotransmitter systems, in particular the cholinergic system, are consistent features of Alzheimer s disease (AD). Abeta is thought to play a critical role in the pathogenesis of AD and it has therefore become a target of interest as regards a therapeutic approach. LÄS MER