Sökning: "intravenous glucose tolerance test"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden intravenous glucose tolerance test.

1. 1. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

   Författare :Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

   Sammanfattning : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. LÄS MER

3. 2. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

   Författare :Oskar Alskär; Maria C Kjellsson; Mats O Karlsson; Jenny Y. Chien; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER

4. 3. Pharmacometric Models of Glucose Homeostasis in Healthy Subjects and Diabetes Patients

   Författare :Rikke Meldgaard Røge; Maria Kjellsson; Niels Rode Kristensen; Søren Klim; Mats Karlsson; Roman Hovorka; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucose homeostasis; Type 2 diabetes; IGI model; Mechanismbased; NONMEM; pharmacometrics;

   Sammanfattning : Diabetes is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Several models have been developed for describing the glucose-insulin system. LÄS MER

5. 4. Integrated Modeling of Glucose and Insulin Regulation Following Provocation Experiments

   Författare :Hanna Silber; Mats O. Karlsson; Nicolas Frey; Willem De Winter; Uppsala universitet; []
   Nyckelord :Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : Blood glucose is controlled by a complex system of insulin and other hormones to assure a constant supply of glucose to the tissues. Type 2 diabetes is a metabolic disorder which is characterized by progressively worsening glycemic control due to a relative deficiency of insulin secretion and a decreased response to insulin. LÄS MER

7. 5. Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release

   Författare :Behrous Davani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glucocorticoids; glucocorticoid receptor; Pancreatic beta-cell; Type 2 diabetes; insulin release;

   Sammanfattning : Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta-cells. Glucocorticoids (GCs) exert profound effects on glucose homeostasis. LÄS MER