Sökning: "in vitro angiogenesis assay"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden in vitro angiogenesis assay.

  1. 11. Angiogenesis modulates obesity and insulin sensitivity

    Författare :Jennifer Honek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under physiological conditions. LÄS MER

  3. 12. Inhibition of mPGES-1 as therapeutic strategy in inflammation and cancer

    Författare :Filip Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandin E2 (PGE2) is an inflammatory and oncogenic lipid mediator. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX-1 and COX-2) and the terminal enzyme microsomal prostaglandin E synthase-1 (mPGES-1). LÄS MER

  4. 13. Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling

    Författare :Ileana Ruxandra Botusan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology and pathology to be able to design therapies for several diseases where angiogenesis is dysregulated (either excessive or diminished). LÄS MER

  5. 14. The use of adipose derived stem cells in spinal cord and peripheral nerve repair

    Författare :Mallappa K Kolar; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; adipose derived stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. LÄS MER

  7. 15. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER