Sökning: "genome stability"

Visar resultat 31 - 35 av 113 avhandlingar innehållade orden genome stability.

  1. 31. The function of Smc5/6 in Drosophila development and at the heterochromatin-like locus HMR in budding yeast

    Författare :Martin Tran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The structural maintenance of chromosome 5/6 (Smc5/6) complex is one out of many factors in the cell that maintain genome stability. Smc5/6 has been implicated in processes such as DNA double-strand break (DSB) repair, replication progression, and chromosome segregation. LÄS MER

  3. 32. The puzzling Smc5/6 complex : piecing together functions in segregation and repair

    Författare :Kristian K Carlborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genome stability is essential in order for cells to survive. During their life cycle, parental cells must divide and properly allocate their genetic material to daughter cells. To ensure correct distribution, multiple proteins are involved in replicating and segregating the genome. LÄS MER

  4. 33. Thermodynamics of Peptide Nucleic Acid Interactions with DNA

    Författare :Tommi Ratilainen; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; thermodynamics; enthalpy-entropy compensation; ionic strength; nucleic acids; fluorescence energy transfer; PNA; calorimetry; sequence-specific binding;

    Sammanfattning : Peptide Nucleic Acid (PNA) is a DNA mimic with the natural nucleobases attached to a charge-neutral pseudopeptide backbone. It has remarkably strong and sequence-specific binding affinity to natural nucleic acids (DNA and RNA), mainly attributed to the lack of charge in the PNA backbone. LÄS MER

  5. 34. Biology of a small RNA virus that infects Drosophila melanogaster

    Författare :Sajna Anand Sadanandan; Dan Hultmark; Francis Jiggins; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nora virus; Drosophila melanogaster; virus biology; host-pathogen interaction; molekylärbiologi; Molecular Biology;

    Sammanfattning : Drosophila melanogaster has been extensively used as a model organism to study diverse facets of biology, including host-pathogen interactions and the basic biology of its pathogens. I have used the fruit fly as a model to study elementary aspects of Nora virus biology, such as the role of the different proteins encoded by the virus genome. LÄS MER

  7. 35. Comparative genomics and molecular characterization of N-alpha acetyltransferase in trypanosomes for drug target identification

    Författare :Stephen Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Trypanosoma cruzi and Trypanosoma brucei are flagellated protozoan parasites that cause Chagas disease and African trypanosomiasis in Latin American and African countries, respectively. Currently, over 8 million people are infected with T. cruzi and about 25 million more are at risk. About half a million people are affected by T. LÄS MER