Sökning: "genetic variance"

Visar resultat 6 - 10 av 94 avhandlingar innehållade orden genetic variance.

  1. 6. The evolution of sexual dimorphism and its genetic underpinnings

    Författare :Philipp Kaufmann; Elina Immonen; Tim Connallon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sexual conflict; sex-specific dominance; maintenance of genetic variance; sexual antagonism; sex chromosomes; Y haplotypes; artificial selection; sexual dimorphism; Callosobruchus maculatus; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Sexual dimorphism often constitutes the largest phenotypic variance within species but it is puzzling how sexual dimorphisms evolve because most of the genome is shared between the sexes. Sexually antagonistic (SA) selection on a shared genome sets the stage for intralocus sexual conflict. LÄS MER

  3. 7. Complex Trait Genetics : Beyond Additivity

    Författare :Simon Forsberg; Örjan Carlborg; Julien Ayroles; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genetic interactions; epistasis; additivity; GWAS; vGWAS; Genetic mapping; yeast; Arabidopsis Thaliana; dog; Genetik; Genetics;

    Sammanfattning : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. LÄS MER

  4. 8. Quantitative Trait Evolution in a Changing Environment in a Seed Beetle

    Författare :Lára R. Hallsson; Mats Björklund; Derek A. Roff; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantitative trait; genetic variance; environmental change; temperature; seed beetle; sexual dimorphism; plasticity; inheritance; Animal Ecology; Zooekologi;

    Sammanfattning : During the last decades the climate has been changing more rapidly than in the preceding periods. This is for instance characterized by an increase in temperature. Interestingly, such changes in the environment are not necessarily constant over time as they often show high levels of fluctuation. LÄS MER

  5. 9. Genetic studies of depressive symptoms

    Författare :Mårten Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Depressive Symptoms; Twin; Heritability; Serotonin receptor 2A; Serotonin transporter; MAOA; MAOB; Thrombocyte MAO activity; Linkage Disequilibrium.;

    Sammanfattning : This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. LÄS MER

  7. 10. Statistical genetic analysis of family data

    Författare :Benjamin H Yip; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Variance component; ascertainment; population-based family data; Generalized linear mixed model; binary trait; quantitative genetics;

    Sammanfattning : The importance of genetic determinants and risk factors of diseases has been consistently recognized in genetic epidemiology, which is one of the fastest growing areas in genomic medicine. Familial clustering is a common characteristic of genetic related phenotypes, providing vital insights into the etiology of diseases by establishing the relative contribution of genetic and environmental factors. LÄS MER