Sökning: "genetic variance"

Visar resultat 11 - 15 av 94 avhandlingar innehållade orden genetic variance.

1. 11. Development of Variance Component Methods for Genetic Dissection of Complex Traits

   Författare :Francois Besnier; Örjan Calborg; Miguel Perez-Enciso; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Genetik; Genetics;

   Sammanfattning : This thesis presents several developments on Variance component (VC) approach for Quantitative Trait Locus (QTL) mapping. The first part consists of methodological improvements: a new fast and efficient method for estimating IBD matrices, have been developed. LÄS MER

3. 12. The genetic architecture of sexual dimorphism

   Författare :Robert Griffin; Urban Friberg; Alexei Maklakov; Jon Ågren; Russell Bonduriansky; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; evolution; intralocus sexual conflict; sex chromosomes; sexually antagonistic selection; sexual dimorphism;

   Sammanfattning : Phenotypic differences between the sexes evolve largely because selection favours a different complement of traits in either sex. Theory suggests that, despite its frequency, sexual dimorphism should be generally constrained from evolving because the sexes share much of their genome. LÄS MER

4. 13. Genetic determinants of breast cancer risk

   Författare :Jingmei Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast Neoplasms;

   Sammanfattning : The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches. In an attempt to identify common disease susceptibility alleles for breast cancer, we started off with a hypothesis-free approach, and performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls. LÄS MER

5. 14. Genetic variance and covariance components for across population evaluation of Brown Swiss cattle

   Författare :Anne Loberg; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Dairy cattle breeding is an international business, with trade of animal material across populations. Interbull performs international genetic evaluations of dairy bulls, enabling fair comparisons across populations. LÄS MER

7. 15. Inbreeding, Effective Population Sizes and Genetic Differentiation : A Mathematical Analysis of Structured Populations

   Författare :Fredrik Olsson; Ola Hössjer; Steinar Engen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; matematisk statistik; Mathematical Statistics;

   Sammanfattning : This thesis consists of four papers on various aspects of inbreeding, effective population sizes and genetic differentiation in structured populations, that is, populations that consist of a number of subpopulations. Three of the papers concern age structured populations, where in the first paper we concentrate on calculating the variance effective population size (NeV) and how NeV depends on the time between measurements and the weighting scheme of age classes. LÄS MER