Sökning: "genetic interactions"

Visar resultat 1 - 5 av 429 avhandlingar innehållade orden genetic interactions.

  1. 1. Genetic Determinants of Dyslipidemia

    Författare :Tibor V Varga; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

    Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

  3. 2. Genetic Studies of Rheumatoid Arthritis using Animal Models

    Författare :Niklas Nordquist; William Dietrich; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. LÄS MER

  4. 3. Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality

    Författare :Gull Rukh; Diabetes - kardiovaskulär sjukdom; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetic variants; copy number variants; genetic risk score; BMI; gene-diet interactions; annual weight change; substantial weight gain; sugar-sweetened beverages; mortality; Mendelian randomization;

    Sammanfattning : Obesity is one of the major health concerns that has reached epidemic proportions globally. It is generally believed to be a result of interactions between genetic and environmental factors. LÄS MER

  5. 4. Complex Trait Genetics : Beyond Additivity

    Författare :Simon Forsberg; Örjan Carlborg; Julien Ayroles; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genetic interactions; epistasis; additivity; GWAS; vGWAS; Genetic mapping; yeast; Arabidopsis Thaliana; dog; Genetik; Genetics;

    Sammanfattning : The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene variants combine their effects in an additive manner. This thesis explores aspects of genetics that cannot be fully captured using such additive models. LÄS MER

  7. 5. Phenolics, Nitrogen, and Biotic Interactions : A Study of Phenylpropanoid Metabolites and Gene Expression in the Leaves of Populus tremula

    Författare :Vicki Huizu Decker; Benedicte Riber Albrectsen; George Newcombe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Populus tremula; condensed tannins; salicinoids; phenolics; genetic variation; soil nitrogen fertilization; herbivory; biology; biologi;

    Sammanfattning : European aspen (Populus tremula) is a fast growing tree species, rich in phenolic compounds. Defense theories suggest that soil nitrogen greatly influence plant allocation togrowth and defense; however, the allocation priorities are not well understood. LÄS MER