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Visar resultat 1 - 5 av 118 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Elucidating the Gating Mechanism of Cys-Loop Receptors

    Författare :Özge Yoluk; Erik Lindahl; Philip Biggin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channel; gating; simulation; molecular dynamics; receptor; cys-loop; modelling; Teoretisk kemi och biologi; Theoretical Chemistry and Biology; Biological Physics; Biologisk fysik;

    Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER

  3. 2. Voltage sensor activation and modulation in ion channels

    Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER

  4. 3. Gating mechanisms of ion channels : lifetime properties of gramicidin A dimers in lipid bilayer membranes

    Författare :Avi A. L. Ring; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Scaling and Gating Attosecond Pulse Generation

    Författare :Christoph Heyl; Atomfysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Coherent imaging; Ultrafast electron dynamics; Single attosecond pulses; Attosecond pulse trains; XUV sources; High-order harmonic generation; XUV frequency combs; Fysicumarkivet A:2014:Heyl;

    Sammanfattning : High-order harmonic generation (HHG) provides the basis for attosecond light sources delivering coherent pulses in the extreme ultraviolet spectral region. Such light sources are employed for a variety of applications within imaging, attosecond spectroscopy, and high-precision frequency metrology. LÄS MER

  7. 5. Conformational Changes during Potassium-Channel Gating

    Författare :Jakob Renhorn; Fredrik Elinder; David Engblom; Stephan Pless; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

    Sammanfattning : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. LÄS MER