Sökning: "fluorescence in situ hybridization FISH"

Visar resultat 16 - 20 av 38 avhandlingar innehållade orden fluorescence in situ hybridization FISH.

  1. 16. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

    Författare :Lars Nilsson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

    Sammanfattning : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. LÄS MER

  3. 17. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia

    Författare :Per Bernell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myelodysplastic syndromes; acute myeloid leukemia; FISH; clonality; lineageinvolvement; minimal residual disease; EIPO; GM-CSF.;

    Sammanfattning : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). LÄS MER

  4. 18. Biliary strictures in primary sclerosing cholangitis : aspects on inflammation and malignancy

    Författare :Erik von Seth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary sclerosing cholangitis (PSC) is a rare liver disease that is characterized by chronic inflammation of bile ducts with development of fibrosis and strictures. The pathogenic mechanisms involved in this disease are insufficiently understood. LÄS MER

  5. 19. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells

    Författare :Pär Lundin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. LÄS MER

  7. 20. A microcell hybrid based 'elimination test' in the search for malignancy related genes

    Författare :Stephan Imreh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is focused on the elimination test developed by us (Imreh et al, 1994). The elimination test was designed as a functional test for malignancy related gene identification. Its task is to follow the cytogenetic and molecular alterations on single normal chromosomes transferred into tumor cells. LÄS MER