Sökning: "digital methods"

Visar resultat 21 - 25 av 1897 avhandlingar innehållade orden digital methods.

1. 21. Benefits of Digital Technical Information

   Författare :Karin Ahlin; Erik A. M. Borglund; Lena-Maria Öberg; Tero Päivärinta; Pasi Tyrväinen; Mittuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; digital technical information; benefit; intangible benefit; interpretative research; manufacturing organization; digital teknikinformation; nytta; omätbara nyttor; tolkande forskning; tillverkande organisation;

   Sammanfattning : In our daily work life, we use a wealth of information, including a category of information produced as a part of products and their life-cycle phases, named digital technical information (DTI). Manufacturing organizations focus more often on the product than on DTI, because DTI’s impact seems almost invisible, despite its crucial role to the product and its life-cycle phases, development, production, maintenance, and destruction. LÄS MER

3. 22. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

   Författare :Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. LÄS MER

4. 23. Hybrid Methods for Unsteady Fluid Flow Problems in Complex Geometries

   Författare :Jing Gong; Jan Nordström; Gunilla Efraimsson; Mark H. Carpenter; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hybrid methods; finite difference methods; finite volume methods; coupling procedure; stability; efficiency; artificial dissipation; Numerical analysis; Numerisk analys; Scientific Computing; Beräkningsvetenskap; Beräkningsvetenskap med inriktning mot numerisk analys;

   Sammanfattning : In this thesis, stable and efficient hybrid methods which combine high order finite difference methods and unstructured finite volume methods for time-dependent initial boundary value problems have been developed. The hybrid methods make it possible to combine the efficiency of the finite difference method and the flexibility of the finite volume method. LÄS MER

5. 24. Uncertainty Quantification and Numerical Methods for Conservation Laws

   Författare :Per Pettersson; Jan Nordström; Gianluca Iaccarino; Gunilla Kreiss; Rémi Abgrall; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; uncertainty quantification; polynomial chaos; stochastic Galerkin methods; conservation laws; hyperbolic problems; finite difference methods; finite volume methods; Beräkningsvetenskap med inriktning mot numerisk analys; Scientific Computing with specialization in Numerical Analysis;

   Sammanfattning : Conservation laws with uncertain initial and boundary conditions are approximated using a generalized polynomial chaos expansion approach where the solution is represented as a generalized Fourier series of stochastic basis functions, e.g. orthogonal polynomials or wavelets. LÄS MER

7. 25. Digital Electrical DNA Sensing

   Författare :Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
   Nyckelord :DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

   Sammanfattning : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. LÄS MER