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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The emotional motor system and gastrointestinal symptoms

    Författare :Pontus Karling; Lars Agréus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anxiety; ANS; autonomic nervous system; cortisol; DST; emotional motor system; functional; gastrointestinal symptoms; GSRS-IBS; gut; HADS; heart rate variability; HPA axis; IBS; irritable bowel syndrome; stress; unipolar depression; val158met COMT polymorphism; Gastroenterology; Gastroenterologi;

    Sammanfattning : There is a significant comorbidity between anxiety/depression and functional gastrointestinal syndromes, such as irritable bowel syndrome (IBS) and functional dyspepsia. The pathophysiological link between emotions and the gut is not known. LÄS MER

  3. 2. Individual glucocorticoid sensitivity in the human

    Författare :Urban Knutsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hypothalamic-pituitary-adrenal axis; cortisol; dexamethasone suppression test; adrenocorticotropin stimulation test; glucocorticoid receptor mRNA; Metallothionein mRNA;

    Sammanfattning : The expanding use of inhaled and intranasal glucocorticoid (Gc) preparations for treatment of mild-to-moderate asthma and allergic rhinitis has in the last decade greatly increased the number of adults and children chronically exposed to exogenous glucocorticoids. In general, current topical glucocorticoid therapies appear to be well tolerated. LÄS MER

  4. 3. Clinical studies of biomarkers in suicide prediction

    Författare :Jussi Jokinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suicide; suicide attempt; HPA axis; dexamethasone suppression test DST ; serum cortisol; Receiver Operating Characteristic ROC ; serotonin; CSF 5-HIAA; depression; prediction; suicide intent; hopelessness;

    Sammanfattning : Suicide is a major clinical problem in psychiatry and suicidal behaviours can be seen as a nosological entity per se. Predicting suicide is difficult due to its low base-rate and the limited specificity of clinical predictors. LÄS MER

  5. 4. Light treatment in seasonal and nonseasonal depression : diagnostic, clinical and neurendocrine studies

    Författare :Björn-Erik Thalén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Depression; seasonal; nonseasonal; light treatment; clinical ratings; melatonin; cortisol; ACTH; CRH; dexamethasone suppression testBj rn-Erik Thalen; 1996Printed in Sweden by Repro Print; Stockholm.;

    Sammanfattning : There is a need for evaluation of new treatment modalities in depression. The aims of this thesis were to investigate the effect of 2 hours of daily light treatment for 10 days in patients with a major depression with seasonal or nonseasonal pattern and to study subgroups of depressed patients with respect to clinical, demographic, and neuroendocrine factors, the effect of exposure to bright light, dexamethasone suppression test, CRH stimulation and the hormonal effect of light exposure on healthy controls. LÄS MER

  7. 5. Affective disorders : multivariate investigations of clinical and biological variables

    Författare :Björn Wahlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Affective disorders; psychiatric symptoms; classification; unipolardepression; bipolar disorder; cortisol; melatonin; monoamine oxidase; principle componentanalysis.;

    Sammanfattning : This thesis is a methodological and clinical investigation of patients with affective disorders. The goal of the study was to determine the extent to which biological and clinical measures may cluster clinical subpopulations. Analytical and statistical procedures were applied for this purpose. LÄS MER