Sökning: "principle componentanalysis."

Hittade 2 avhandlingar innehållade orden principle componentanalysis..

  1. 1. Affective disorders : multivariate investigations of clinical and biological variables

    Författare :Björn Wahlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Affective disorders; psychiatric symptoms; classification; unipolardepression; bipolar disorder; cortisol; melatonin; monoamine oxidase; principle componentanalysis.;

    Sammanfattning : This thesis is a methodological and clinical investigation of patients with affective disorders. The goal of the study was to determine the extent to which biological and clinical measures may cluster clinical subpopulations. Analytical and statistical procedures were applied for this purpose. LÄS MER

  3. 2. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Författare :Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Sammanfattning : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. LÄS MER