Sökning: "desensitization"

Visar resultat 26 - 30 av 42 avhandlingar innehållade ordet desensitization.

  1. 26. Levosimendan in early experimental sepsis: effects on the heart and hepatosplanchnic circulation

    Författare :Doris Cunha Goncalves; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; septic shock; myocardial oxygen consumption; myocardial dysfunction; levosimendan; endotoxin; contractility; catecholamines; calcium sensitizer; cardiotonic agents; splanchnic perfusion;

    Sammanfattning : Sepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. LÄS MER

  3. 27. Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat

    Författare :Peter Ericsson; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The ECL cells constitute the major endocrine cell population in the acid-producing part of the stomach. Gastrin from G cells in the antrum is the main stimulus of gastric acid secretion. Gastrin stimulates the ECL cells in the oxyntic mucosa to mobilize histamine, which in turn stimulates the parietal cells to produce hydrochloric acid. LÄS MER

  4. 28. AB0-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab

    Författare :Helena Genberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : 5As the demand for kidney transplantation is constantly growing methods to expand the donor pool have become increasingly important. AB0-incompatibility has hitherto been regarded as an absolute contraindication to living donor donation. LÄS MER

  5. 29. Regulation of NMDA receptor properties by amino acids and cations : a biochemical and electrophysiological study

    Författare :Yun Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NMDA receptor; Glutamate; Glycine; [3H]MK-801 binding; Magnesium; Calcium; Tris; Potassium; Sodium; Proton; Xenopus oocytes; Spinal cord; Cerebral cortex; Receptor binding; Electrophysiology;

    Sammanfattning : NMDA receptors are glutamate-regulated ion channels that are permeable to Ca2+, Na+ and K+ and are sensitive to voltage-dependent Mg2+-block. To investigate the modulatory effects of amino acids and cations on NMDA receptors and the possible regional differences in the pharmacology of NMDA receptors, I used mainly two techniques in this thesis: electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801 in membrane preparations from the rat cerebral cortex and spinal cord. LÄS MER

  7. 30. Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets

    Författare :Christina Kalderén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies and they have, since they were cloned in the 1990ies, been regarded as attractive targets for development of drugs against cancer, viral infections, and inflammatory/autoimmune diseases. LÄS MER