Sökning: "Yun Liu"

Hittade 2 avhandlingar innehållade orden Yun Liu.

  1. 1. Regulation of NMDA receptor properties by amino acids and cations : A biochemical and electrophysiological study

    Författare :Yun Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NMDA receptor; Glutamate; Glycine; [3H]MK-801 binding; Magnesium; Calcium; Tris; Potassium; Sodium; Proton; Xenopus oocytes; Spinal cord; Cerebral cortex; Receptor binding; Electrophysiology.;

    Sammanfattning : NMDA receptors are glutamate-regulated ion channels that arepermeable to Ca2+, Na+ and K+ andare sensitive to voltage-dependent Mg2+-block. Toinvestigate the modulatory effects of amino acids and cations on NMDAreceptors and the possible regional differences in the pharmacologyof NMDA receptors, I used mainly two techniques in this thesis:electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801in membrane preparations from the rat cerebral cortex and spinalcord. LÄS MER

  2. 2. Smooth muscle hypertrophy and the IGF-system

    Författare :Yun Chen; David R. Clemmons; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-! (IGF-I) has both metabolic and mitogenic effects on smooth muscle cells (SMCs). The effects of IGF-I are modified by a group of binding proteins (IGFBPs). The present study was devoted to smooth muscle hypertrophy and the IGF-system in smooth muscle under different conditions. LÄS MER