Sökning: "desensitization"
Visar resultat 21 - 25 av 42 avhandlingar innehållade ordet desensitization.
21. ß-Adrenergic receptor gene polymorphism in dilated cardiomyopathy. Clinical and functional relevance
Sammanfattning : During normal physiological conditions, catecholamines induce positive inotropic and chronotropic responses in the heart through a ß-adrenergic receptor (AR)-activated pathway. The agonist-bound ßAR selectively interacts with the stimulatory Gs-protein, which activates adenylyl cyclase, catalyzing cAMP formation. LÄS MER
22. Adrenergic receptors in brown adipose tissue
Sammanfattning : The purpose of this study was to identify adrenergic receptors and to investigate their regulation of physiological processes in brown adipose tissue.Isolated hamster brown fat cells and plasma membrane fractions contained a high number of α1- and β1-adrenergic receptors, as assessed by direct radioligand binding techniques using (3H)prazosin and (-)(3H)dihydroalprenolol, respectively. LÄS MER
23. Role of caveolin-1 in brown adipose tissue
Sammanfattning : Caveolae are 50-100 nm invaginations in the plasma membrane. Caveolae and the protein caveolin-1 (Cav1) have been shown to be important in many signaling pathways in different cell types; however, in some cell types caveolae and Cav1 do not seem to affect the investigated signaling pathways. LÄS MER
24. Physiological and pathophysiological regulation of ECL-cell activity
Sammanfattning : The ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They produce and secrete histamine and chromogranin A-derived peptides in response to circulating gastrin. Mobilized histamine stimulates acid secretion from adjascent parietal cells. LÄS MER
25. Signal transduction and calcium sensitivity of smooth muscle contraction
Sammanfattning : Smooth muscles are components of several physiologically important organs and often involved in disease. Smooth muscle contraction is regulated by variations in intracellular [Ca2+]; increased levels activate the myosin light chain kinase (MLCK) which phosphorylates myosin and initiates contraction. LÄS MER