Sökning: "cystic fibrosis transmembrane conductance regulator"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden cystic fibrosis transmembrane conductance regulator.

1. 11. Ion transport in exocrine glands with reference to cystic fibrosis

   Författare :Ailing Zhang; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ion transport; cystic fibrosis; submandibular gland; airway submucosal gland; X-ray microanalysis; cytosolic Ca2 concentration; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

   Sammanfattning : Aspects of ion transport in rat submandibular gland acinar cells at the subcellular level, and the regulation of chloride secretion and calcium mobilization in cultured pig tracheal gland acinar cells were studied with reference to the disease cystic fibrosis.In adult rat submandibular gland acinar cells, both cholinergic and α-adrenergic stimulation induced efflux of K+ and of C1-, but the response was generally less with α-adrenergic stimulation. LÄS MER

3. 12. On Mechanisms Impairing Airway Host Defence in Cystic Fibrosis

   Författare :Sandra Jovic; allergologi och palliativ medicin Lungmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Cystic fibrosis is an inherited disease, caused by mutations of the cystic fibrosis transmembrane conductance regulator gene. The gene codes for a protein that serve as chloride channel. In cystic fibrosis, this protein is lacking or has a defect function resulting in a thick and sticky mucus of the airways. LÄS MER

4. 13. Studies on mechanisms in liver fibrosis

   Författare :Nils Kinnman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bile duct epithelial cell; chernotaxis; cholestasis; cystic fibrosis; cystic fibrosis transmembrane conductance regulator; endothelin; hepatic stellate cell; hepatitis C virus; liver fibrosis; platelet-derived growth factor; platelet-derived growth factor receptor [beta]; smooth muscle [alpha]-actin; transforming growth factor- [beta]; tumor necrosis factor-[alpha];

   Sammanfattning : The aim of the present study was to elucidate mechanisms involved in liver fibrogenesis, the wound healing response of the liver to chronic injury. A role for TNF-[alpha] and all three isoforms of TGF-[beta] in the pathogenesis of hepatitis C related liver disease was suggested by the finding of increased expression of TGF-[beta]1-3, latent TGF-[beta] binding protein (LTBP), and TNF-[alpha] by immunohistochemistry in areas of inflammation and fibrosis in liver tissue from untreated patients with hepatitis C. LÄS MER

5. 14. Common respiratory virus infections in cystic fibrosis : from immunity to vaccine

   Författare :Renata Utorova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water transport across epithelial cell membranes. LÄS MER

7. 15. Aspects on puberty and fertility among females with cystic fibrosis a multidisciplinary study on humans and rats

   Författare :Marie Johannesson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cystic fibrosis; puberty; fertility; hormonal profiles; CFTR mRNA; MDR mRNA; rat brain; pregnant rat lung; psychosocial aspects.;

   Sammanfattning : Due to intensified symptomatic treatment, a majority of patients with cystic fibrosis (CF) now go through puberty and reach adulthood. This provides new challenges for the CF health care providers. LÄS MER