Sökning: "constraint-based modeling"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden constraint-based modeling.

1. 1. Systems biology of yeast metabolism - Understanding metabolism through proteomics and constraint-based modeling

   Författare :Carl Malina; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteomics; metabolism; Systems biology; constraint-based modeling; yeast;

   Sammanfattning : Metabolism is the set of all chemical reactions that occur inside of cells. By providing all the building blocks that are required for sustaining a cellular state and cell proliferation, metabolism is at the core of cellular function. Therefore, in order to understand cellular function it is important to understand cellular metabolism. LÄS MER

3. 2. Constraint-based modeling of yeast metabolism and protein secretion

   Författare :Feiran Li; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein secretion; metabolism; yeast evolution; genome-scale metabolic model; phenotype diversity;

   Sammanfattning : Yeasts are extensively exploited as cell factories for producing alcoholic beverages, biofuels, bio-pharmaceutical proteins, and other value-added chemicals. To improve the performance of yeast cell factories, it is necessary to understand their metabolism. LÄS MER

4. 3. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

   Författare :Avlant Nilsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

   Sammanfattning : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. LÄS MER

5. 4. Application of the Seismic Reflection Method in Mineral Exploration and Crustal Imaging : Contributions to Hardrock Seismic Imaging

   Författare :Omid Ahmadi; Christopher Juhlin; Alireza Malehmir; Gilles Bellefleur; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Seismic reflection; Hardrock; Mineral exploration; Crustal imaging; Interpretation; Modeling; Geofysik med inriktning mot fasta jordens fysik; Geophysics with specialization in Solid Earth Physics;

   Sammanfattning : The seismic reflection method has been used extensively in mineral exploration and for imaging crustal structures within hardrock environments. In this research the seismic reflection method has been used and studied to address problems associated with hardrock settings. LÄS MER

7. 5. Managing the Complexity in Embedded and Cyber-Physical System Design : System Modeling and Design-Space Exploration

   Författare :Seyed Hosein Attarzadeh Niaki; Ingo Sander; Christian Haubelt; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : To cope with the increasing complexity of embedded and cyber-physical system design, different system-level design approaches are proposed which start from abstract models and implement them using design flows with high degrees of automation. However, creating models of such systems and also formulating the mathematical problems arising in these design flows are themselves challenging tasks. LÄS MER