Sökning: "computational mathematical modeling"

Visar resultat 6 - 10 av 86 avhandlingar innehållade orden computational mathematical modeling.

1. 6. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

   Författare :Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

   Sammanfattning : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. LÄS MER

3. 7. Mixed-Integer Optimization Modeling for the Simultaneous Scheduling of Component Replacement and Repair

   Författare :Gabrijela Obradovic; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mathematical Modeling; Workshop Scheduling; Maintenance Optimization; Simultaneous Scheduling; Mixed-Integer Linear Optimization; Multi-Objective Optimization; Contracting Forms;

   Sammanfattning : Maintenance is a critical aspect of many industries, playing an indispensable role in ensuring the optimal functionality, reliability, and longevity of various assets, equipment, and infrastructure. For a system to remain operational, maintenance of its components is required, and for the industry to optimize its operations, establishment of good maintenance policies and practices is vital. LÄS MER

4. 8. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

   Författare :Jacob Leander; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pharmacometrics; pharmacokinetics; mixed effects; drug development; pharmacodynamics; parameter estimation; time-to-event; mathematical modeling; dynamical systems;

   Sammanfattning : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. LÄS MER

5. 9. Multiscale Modeling in Systems Biology : Methods and Perspectives

   Författare :Adrien Coulier; Andreas Hellander; Mark Chaplain; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; computational systems biology; high performance computing; Bayesian inference; stochastic simulation; cell mechanics; Scientific Computing; Beräkningsvetenskap;

   Sammanfattning : In the last decades, mathematical and computational models have become ubiquitous to the field of systems biology. Specifically, the multiscale nature of biological processes makes the design and simulation of such models challenging. LÄS MER

7. 10. Computational Ice Sheet Dynamics : Error control and efficiency

   Författare :Josefin Ahlkrona; Per Lötstedt; Jesse Johnson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ice sheet modelling; stokes equations; shallow ice approximation; finite element method; perturbation expansions; non-newtonian fluids; free surface flow; Scientific Computing; Beräkningsvetenskap;

   Sammanfattning : Ice sheets, such as the Greenland Ice Sheet or Antarctic Ice Sheet, have a fundamental impact on landscape formation, the global climate system, and on sea level rise. The slow, creeping flow of ice can be represented by a non-linear version of the Stokes equations, which treat ice as a non-Newtonian, viscous fluid. LÄS MER