Sökning: "Jacob Leander"

Hittade 2 avhandlingar innehållade orden Jacob Leander.

  1. 1. Contributions to nonlinear mixed-effects modeling

    Författare :Jacob Leander; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :nonlinear mixed-effects models; stochastic differential equations; parameter estimation; extended Kalman filter; sensitivity equations; stochastic differential equations;

    Sammanfattning : The topic of this thesis is nonlinear mixed-effects models. A nonlinear mixed-effects model is a hierarchical regression model used to analyze measurements from several individuals simultaneously, which allows sharing of information between similar individuals. LÄS MER

  2. 2. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development

    Författare :Jacob Leander; Chalmers University of Technology; []
    Nyckelord :time-to-event; mathematical modeling; dynamical systems; parameter estimation; pharmacodynamics; mixed effects; drug development; pharmacokinetics; pharmacometrics;

    Sammanfattning : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. LÄS MER