Sökning: "chloroquine"

Visar resultat 11 - 15 av 46 avhandlingar innehållade ordet chloroquine.

  1. 11. Half-sandwich complexes with amino-quinoline ligands - synthesis, antiplasmodial and antimycobacterial activities

    Författare :Erik Ekengard; Kemisk fysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; malaria; tuberculosis; half-sandwich compound; drug-resistance; bioorganometallic chemistry;

    Sammanfattning : Malaria and tuberculosis are two of the most deadly infectious diseases that exist. Both diseases predominantly affect the most vunerable parts of society. Additionally the treatment of both diseases are complicated by growing and spreading resistance against the drugs used to treat them. LÄS MER

  3. 12. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity

    Författare :Martijn Manson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. LÄS MER

  4. 13. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

    Författare :Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. LÄS MER

  5. 14. The molecular basis of Plasmodium falciparum resistance to the antimalarial lumefantrine

    Författare :Christin Sisowath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria control is compromised by the development and spread of Plasmodium falciparum resistance to antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. Artemisinin based combination therapy (ACT) has been implemented in almost all malaria endemic areas in an attempt to suppress drug resistance. LÄS MER

  7. 15. Malaria control measures : impact on malaria and anaemia in holoendemic area of rural coastal Tanzania

    Författare :Zul Premji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria is a major public health problem in tropical Africa. It is particularly the main killer disease in children below five years and its health impact is most severe in the rural areas. Malarial anaemia is believed to be the main complication in high endemic areas. LÄS MER