Sökning: "drug-resistance"

Visar resultat 1 - 5 av 229 avhandlingar innehållade ordet drug-resistance.

1. 1. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

   Författare :Bertil Jonsson; Uppsala universitet; []
   Nyckelord :Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. LÄS MER

3. 2. Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics

   Författare :Britt-Marie Frost; Henrik Schröder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; cytotoxicity; drug resistance; pharmacokinetics; Acute lymphoblastic leukemia; childhood; in vitro assay; vincristine; doxorubicin; Down`s syndrome; CHS 828.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

   Sammanfattning : The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. LÄS MER

4. 3. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

   Författare :Eva Knaust; Linköpings universitet; []
   Nyckelord :Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

   Sammanfattning : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. LÄS MER

5. 4. Drug resistance in mycobacterium tuberculosis

   Författare :Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

   Sammanfattning : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. LÄS MER

7. 5. Biological markers in breast cancer and acute leukaemia with focus on drug resistance

   Författare :Elisabet Tina; Ulf Tidefelt; Sten Wingren; Mats G. Karlsson; Jan-Ingvar Jönsson; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; acute leukaemia; drug resistance; toposiomerase IIa; BCRP; HER2; SLC25A43; flow cytometry; real time PCR; whole genome screening; MEDICINE; MEDICIN; Oncology; Onkologi; Biomedicin; Biomedicine;

   Sammanfattning : .... LÄS MER