Sökning: "carbohydrate conformations"

Visar resultat 6 - 9 av 9 avhandlingar innehållade orden carbohydrate conformations.

  1. 6. Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy

    Författare :Ulrika Olsson; Göran Widmalm; Corine Sandström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; conformation; Escherichia coli; lipopolysaccharide; O-antigen; carbohydrates; structure; isotopic labelling; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations. LÄS MER

  3. 7. Conformational Studies of Biologically Active Peptides

    Författare :Björn Walse; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. LÄS MER

  4. 8. NMR spectroscopy and MD simulations of carbohydrates

    Författare :Elin Säwén; Göran Widmalm; Manuel Martin Pastor; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR specroscopy; MD simulations; carbohydrates; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Knowledge about the structure, conformation and dynamics of carbohydrates is important in our understanding of the way carbohydrates function in biological systems, for example in intermolecular signaling and recognition. This thesis is a summary of five papers studying these properties in carbohydrate-containing molecules with NMR spectroscopy and molecular dynamics simulations. LÄS MER

  5. 9. Aspects of N-glycosylation in human IgE

    Författare :Johanna Da Luz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The medical interest of allergy in industrialised societies has generated a much greater knowledge about the pathophysiology of IgE-mediated responses than about its normal physiological role. Because of the central role of IgE in allergic inflammation, neutralisation of effector functions and inhibition of IgE-synthesis are attractive means of therapy. LÄS MER