Sökning: "protein-peptide interactions"

Hittade 4 avhandlingar innehållade orden protein-peptide interactions.

  1. 1. Conformational Studies of Biologically Active Peptides

    Författare :Björn Walse; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. LÄS MER

  3. 2. Using peptide-phage display to capture conditional motif-based interactions

    Författare :Gustav Sundell; Ylva Ivarsson; Per Jemth; Attila Reményi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interaction; PDZ domain; phosphorylation; peptide-phage display; ProP-PD; phospho-peptide; phosphomimetic substitution; Scribble; NMR; DLG1; PTM; affiinity; Biokemi; Biochemistry;

    Sammanfattning : This thesis explores the world of conditional protein-protein interactions using combinatorial peptide-phage display and proteomic peptide-phage display (ProP-PD). Large parts of proteins in the human proteome do not fold in to well-defined structures instead they are intrinsically disordered. LÄS MER

  4. 3. Gene-environment interactions in rheumatoid arthritis : quantification and characterization of contributing factors

    Författare :Xia Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterised by persistent synovitis, systemic inflammation and autoantibodies. RA has a complex aetiology with the involvement of genetic factors and environmental triggers, and their interactions. LÄS MER

  5. 4. Mechanisms and modulation of experimental allergic encephalomyelitis as basis for treatment of multiple sclerosis

    Författare :Ling-Yun Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Its etiology is unknown and there exists no cure. LÄS MER