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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Satellite cells in human skeletal muscle : molecular identification quantification and function

    Författare :Mona Lindström; Lars-Eric Thornell; Hannu Kalimo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; satellite cell markers; NCAM; Pax7; MyoD; myogenin; DLK1 FA1; c-Met; human skeletal muscle; immunohistochemistry; muscle growth; muscle hypertrophy; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; anatomi; Human Anatomy;

    Sammanfattning : Skeletal muscle satellite cells located between the plasma membrane and the basal lamina of muscle fibres, could for many years, only be studied in situ by electron microscopy. The introduction of immunohistochemistry and the discovery of molecular markers of satellite cells then made them accessible for light microscopic studies and a wealth of information is today available. LÄS MER

  3. 2. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Författare :Xianghua Zhou; Göteborgs universitet; []
    Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER

  4. 3. Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications

    Författare :Mario A Economou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Uveal melanoma; exudative AMD; IGF-1R; c-Met; prognostic markers; metastasis; oral treatment; VEGF;

    Sammanfattning : Uveal melanoma is the most common primary intraocular malignant tumor in adults with 30% to 50% of patients that ultimately succumb to metastatic disease, mainly to the liver. Although new diagnostic and therapeutic tools have been developed during the most recent years, only the eye conservation rate has been achieved, while the survival rate remains poor. LÄS MER

  5. 4. Periodontitis and coronary artery disease : Studies on the association between periodontitis and coronary artery disease

    Författare :Carin Starkhammar Johansson; Arina Richter; Nils Ravald; Björn Klinge; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Periodontitis and coronary artery disease (CAD) are highly prevalent in Sweden’s population; both diseases have complicated pathogeneses and clinical manifestations due to immune-system triggered inflammation. Research in recent years reported that inflammation is a significant active participant in many chronic diseases. LÄS MER

  7. 5. Experimental studies on the effects of hepatocyte-based liver support

    Författare :Helene Lilja; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Liver transplantation is limited by lack of donors and consequently there is a need to develop liver support/replacement therapies, such as hepatocyte transplantation (HcTx) and artificial livers. In the present thesis, the effects of these therapies were investigated. First, we established a technique of isolating fetal hepatocytes (FH). LÄS MER