Sökning: "MyoD"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet MyoD.

1. 1. Satellite cells in human skeletal muscle : molecular identification quantification and function

   Författare :Mona Lindström; Lars-Eric Thornell; Hannu Kalimo; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; satellite cell markers; NCAM; Pax7; MyoD; myogenin; DLK1 FA1; c-Met; human skeletal muscle; immunohistochemistry; muscle growth; muscle hypertrophy; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; anatomi; Human Anatomy;

   Sammanfattning : Skeletal muscle satellite cells located between the plasma membrane and the basal lamina of muscle fibres, could for many years, only be studied in situ by electron microscopy. The introduction of immunohistochemistry and the discovery of molecular markers of satellite cells then made them accessible for light microscopic studies and a wealth of information is today available. LÄS MER

3. 2. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

   Författare :Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER

4. 3. Extraocular Muscles in Amyotrophic Lateral Sclerosis

   Författare :Anton Tjust; Fatima Pedrosa Domellöf; Mona Lindström; Thomas Brännström; Eva Hedlund; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; EOM; Satellite cells; innervation; neuromuscular disease; neurodegenerative disease; anatomi; Human Anatomy;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of motor neurons characterized by muscle paralysis and death within 3-5 years of onset. However, due to unknown mechanisms, the extraocular muscles (EOMs) remain remarkably unaffected. LÄS MER

5. 4. Adrenergic signaling in insulin-sensitive tissues

   Författare :Daniel L. Yamamoto; Tore Bengtsson; Barbara Cannon; Michael Cawthorne; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Adrenergic; Glucose; Signaling; Skeletal muscle; Animal physiology; Zoofysiologi; zoofysiologi; Zoological physiology;

   Sammanfattning : Glucose metabolism in insulin-sensitive tissues such as skeletal muscle and adipose tissue is tightly regulated by external stimuli. Metabolic changes in these tissues have direct effects on whole body metabolism. Such metabolic changes can be induced or influenced by adrenergic stimulation. LÄS MER

7. 5. An exploration of the mechanisms behind peripheral nerve injury

   Författare :Rebecca Wiberg; Liudmila Novikova; Paul Kingham; Ash Mosahebi; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peripheral nerve injury; target organ; spinal motoneurons; primary sensory neurons; degeneration; anatomi; Human Anatomy;

   Sammanfattning : Despite surgical innovation, the sensory and motor outcome after peripheral nerve injury is incomplete. In this thesis, the biological pathways potentially responsible for the poor functional recoveries were investigated in both the distal nerve stump/target organ, spinal motoneurons and dorsal root ganglia (DRG). LÄS MER