Sökning: "F-actin-binding proteins"

Hittade 4 avhandlingar innehållade orden F-actin-binding proteins.

  1. 1. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Författare :Xianghua Zhou; Göteborgs universitet; []
    Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER

  3. 2. Structural Study of the WH2 Family and Filamin: Implications for Actin Cytoskeleton Regulation

    Författare :Adeleke H. Aguda; Robert Robinson; Lars Rask; Lars Backman; Uppsala universitet; []
    Nyckelord :Biochemistry; Actin; Thymosin; Ciboulot; N-WASP; Filamin; Calponin homology domain; WH2; Protein Crystallography; Biokemi;

    Sammanfattning : Cellular processes like motility, chemotaxis, phagocytosis and morphogenesis are dependent on the dynamic regulation of the actin cytoskeleton. This cytoskeleton system is tightly controlled by a number of diverse actin-binding proteins (ABPs) by various mechanisms described as nucleation, polymerization, capping, severing, depolymerization and sequestration. LÄS MER

  4. 3. Phosphatidylinositol phosphate kinases in the moss Physcomitrella patens

    Författare :Laura Saavedra; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Phosphatidylinositol(4,5)bisphosphate, [PtdIns(4,5)P2], is a signalling lipid which is involved in many important processes in animal cells such as cytoskeleton organization, intracellular vesicular trafficking, secretion, cell motility, regulation of ion channels, and nuclear signalling pathways. In contrast to the animal field, much less is known about the roles of PtdIns(4,5)P2 and its synthesizing enzyme, phosphatidylinositol phosphate kinase (PtdInsP kinase), in plants. LÄS MER

  5. 4. Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids

    Författare :Teresia Magnuson Osborn; Göteborgs universitet; []
    Nyckelord :Cytoskeleton; Crosslinking; F-actin; Filamin; Gelsolin; Inflammation; Plasma; Platelet-activating factor; Lysophosphatidic acid; Rheumatoid arthritis;

    Sammanfattning : Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular and extracellular (plasma gelsolin, pGSN) isoforms. LÄS MER