Sökning: "breast cancer resistance protein"

Visar resultat 31 - 35 av 67 avhandlingar innehållade orden breast cancer resistance protein.

  1. 31. Molecular and therapeutic aspects of breast cancer stem cells

    Författare :Ran Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer stem cells (BCSCs) are defined as a minor cellular component in the solid tumor, displaying mammary stem cell properties by expressing embryonic stem cell genes. They are usually undergoing self-. LÄS MER

  3. 32. Cell cycle alterations and 11q13 amplification in breast cancer : prediction of adjuvant treatment response

    Författare :Marie Ahnström Waltersson; Olle Stål; Marie-Louise Fjällskog; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The growth and development of the breast is to a large extent regulated by oestrogens through the oestrogen receptor (ER). Activation of the ERα triggers transcription of genes that are important for cell proliferation and stimulates entry into the G1 phase of the cell cycle. LÄS MER

  4. 33. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

    Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

    Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

  5. 34. Biochemical and Structural Studies on the Adaptor Protein p130Cas

    Författare :Fariborz Nasertorabi; Kathryn R Ely; Lars Liljas; Jyrki Heino; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Integrin signaling; p130Cas; X-ray Crystallography; NMR Spectroscopy; Protein phosphorylation; BCAR-1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. LÄS MER

  7. 35. Potential novel molecular targets for breast cancer diagnosis and treatment

    Författare :Amirhossein Kharman Biz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer possesses the highest incidence among cancers in women worldwide, accounting for approximately 26% of all cancers in women. Due to the discovery of specific predictive and prognostic biomarkers, breast cancer therapy has been significantly promoted in the past decades through the application of more individualized therapies to diverse subcategories with different clinical behavior. LÄS MER