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  1. 1. Synthesis and Applications of P-chirogenic Phosphine Boranes

    Författare :Magnus Johansson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytisine; gold I catalysis lipase; P-chirogenic; desymmetrization; phosphine; enantioselective cyclopropanation. enantioselective deprotonation; chirality; asymmetric synthesis; borane;

    Sammanfattning : AbstractThis thesis reports the independent synthesis of both enantiomers of P-chirogenic phosphine ligands and the building blocks thereof, which are suitable for parallel synthesis efforts and for the generation of more diverse libraries of P-chirogenic compound. The use of P-chirogenic phosphine boranes in transition metal-catalyzed reactions, such as palladium-catalyzed allylic alkylation and amination, is also described. LÄS MER

  3. 2. Asymmetric Synthesis of Dipeptidomimeticsand Phosphine-Boranes - Routes Involving Stereoselective Olefination, Epoxidation, and Lipase-Catalysed Reactions

    Författare :Daniel Wiktelius; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. Acetals - Exploring reactivity for improved carbohydrate synthesis

    Författare :Markus Ohlin; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In my research, I have explored various aspects of acetals and their reactivity. Acetals have a central role in carbohydrate chemistry as an inherent functionality and as versatile protecting groups. The first part of the thesis summarizes results on regioselective reductive openings of benzylidene acetals. LÄS MER

  5. 4. Synthetic studies on naphthoxylosides - labeled compounds and mechanistic studies on acetals

    Författare :Richard Johnsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fluorescent xylosides; Carbohydrates; Naphthoxylosides; Cancer; Mechanistic studies; Radioactive xylosides; Acetals;

    Sammanfattning : Labeled analogs to an antiproliferative naphthoxyloside have been synthesized and evaluated. Our investigations have shown that the fluorescently labeled analogs are poor structural analogs, and the physical and biological properties are altered to a large extent. LÄS MER

  7. 5. Asymmetric Hydrogenations using N, P - Ligated Iridium Complexes

    Författare :Alexander Paptchikhine; Pher G. Andersson; Karl Anker Jørgensen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric hydrogenation; iridium; birch; boronates; fluorine;

    Sammanfattning : The research described in this thesis focuses on the catalytic asymmetric hydrogenation of prochiral olefins using N, P – chelated iridium catalysts. This catalytic system is tolerant to a wide range of substrates and performs better than the well-known ruthenium- and rhodium-catalytic systems for substrates devoid of coordinating groups in proximity of the olefin. LÄS MER