Sökning: "amyloid-beta precursor protein"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden amyloid-beta precursor protein.

  1. 11. Distribution and pathophysiological role of amyloid precursor protein and presenilin 1 : characterization in rats and in vitro studies on the pathogenic arctic mutation

    Författare :Camilla Nilsberth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease is the most common form of dementia that presents a growing dilemma worldwide. Alzheimer's disease is neuropathologically characterized by cerebral atrophy accompanied by deposition of senile plaques and neurofibrillary tangles. LÄS MER

  3. 12. Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death

    Författare :Camilla Hansson Petersen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In several neurodegenerative disorders, including Alzheimer disease (AD) and Parkinson disease (PD), protein aggregation is accompanied by mitochondrial dysfunction. An increasing number of proteins found in mitochondria have multiple localizations. LÄS MER

  4. 13. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites

    Författare :Adnan Halim; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycobiology; Glycoproteomics; Mass Spectrometry;

    Sammanfattning : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. LÄS MER

  5. 14. Alzheimer disease : studies on Abeta and gamma-secretase in human brain

    Författare :Hedvig Welander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia. One hallmark of the disease is the extracellular deposition of amyloid beta-peptide (Abeta) into senile plaques in the brain. Biochemical and genetic studies reveal Abeta as a key player in AD pathogenesis. LÄS MER

  7. 15. Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease

    Författare :Hagit Katzov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Genetic variation; association; ACE; ABCA1; Alzheimer disease; pleiotropy; cardiovascular disease;

    Sammanfattning : To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the fine-resolution mapping of biologically significant genes and regions discerned by linkage analysis. LÄS MER