Sökning: "amyloid-beta precursor protein"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden amyloid-beta precursor protein.

  1. 16. The role of estrogen regulation in brain development and neurodegeneration

    Författare :Linda Nord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen is a steroid hormone which regulates neuronal control of reproduction. It has other important roles in the central nervous system (CNS), including trophic effects on dendritic spine morphology that provide structural plasticity. LÄS MER

  3. 17. The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins

    Författare :Ji-Yeun Hur; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the brain that eventually results in cognitive decline. Characteristic hallmarks of AD are senile plaques containing the amyloid beta-peptide (Abeta) and neurofibrillary tangles containing hyperphosphorylated tau protein. LÄS MER

  4. 18. Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin

    Författare :Faisal Hayat Nazir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; neurogranin; APP; human iPSCs; CSF;

    Sammanfattning : Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. LÄS MER

  5. 19. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Författare :Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER

  7. 20. Studies on gamma-secretase activity and products

    Författare :Jenny Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). LÄS MER