Sökning: "ABCA1"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ABCA1.
1. Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
Sammanfattning : To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the fine-resolution mapping of biologically significant genes and regions discerned by linkage analysis. LÄS MER
2. Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
Sammanfattning : Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and atherosclerosis. LÄS MER
3. Role of GPS2 in epigenome alterations linked to metaflammation
Sammanfattning : Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein pathway suppressor 2 (GPS2) is a key component of the HDAC3 co-repressor complex that has been earlier implicated in cholesterol homeostasis and anti-inflammatory crosstalk. LÄS MER
4. Studies on the regulation of hepatic and intestinal lipid metabolism
Sammanfattning : Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and the effect of mitochondrial (mt)DNA depletion on hepatic β-oxidation of fatty acids. LÄS MER
5. Transcriptional control of liver metabolism and disease by nuclear receptor-corepressor networks
Sammanfattning : Liver lipid metabolism is coordinated via transcriptional networks composed of transcription factors and coregulators. Disturbance of such networks leads to metabolic dysregulation and is linked to the progression of obesity-related metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. LÄS MER