Sökning: "amphiphilic peptide"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden amphiphilic peptide.

  1. 1. Amphiphilic Peptide Interactions with Complex Biological Membranes : Effect of peptide properties on antimicrobial and anti-inflammatory effects

    Författare :Shalini Singh; Martin Malmsten; Per Hansson; Debora Berti; Uppsala universitet; []
    Nyckelord :LPS; Antimicrobial; Peptide; Inflammation; Infections; Liposome; Binding; PEG; Farmaceutisk fysikalisk kemi; Pharmaceutical Physical Chemistry;

    Sammanfattning : With increasing problem of resistance development in bacteria against conventional antibiotics, as well as problems associated with diseases either triggered or enhanced by infection, there is an urgent need to identify new types of effective therapeutics for the treatment of infectious diseases and its consequences. Antimicrobial and anti-inflammatory peptides have attracted considerable interest as potential new antibiotics in this context. LÄS MER

  3. 2. Biomimetic Formation of Calcium Phosphate Based Nanomaterials

    Författare :Wenxiao He; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; superstructure; lyotropic liquid crystal; self-assembly; Calcium phosphate; bone-like apatite; amphiphilic peptide; nanocomposite; biomimetic mineralization;

    Sammanfattning : The intercellular material in bone is a nanocomposite of aligned “hard” inorganics—calcium phosphate (CaP) platelets embedded in the long-range ordered “soft” organic collagen matrix. This elaborate structural arrangement redeems the weaknesses of the individual components (being soft protein or brittle mineral) and gives bone its excellent mechanical properties for the protection and support of our bodies. LÄS MER

  4. 3. Functionalization and characterization of surface supported lipid membranes and their application in cell culture

    Författare :Dorota Thid; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cell - surface interaction; supported phospholipid bilayer; IKVAV; DHA; stem progenitor cells; neural cells; surface analytical techniques; QCM-D; surface functionalization; peptide; cell differentiation; cell attachment; membrane; fatty acid;

    Sammanfattning : Phospholipid bilayers supported on a solid surface constitute a versatile, biomimetic platform for a variety of applications, such as biosensing, drug delivery research, cell engineering and as cell membrane mimics in fundamental cell research. Phosphocholine supported lipid bilayers are resistant to cell attachment in a wide range of conditions, and can be functionalized with bioactive signaling molecules to promote specific interactions with cells. LÄS MER

  5. 4. Development of lipodisks as carriers for cationic amphiphilic peptides

    Författare :Karin Reijmar Brunnström; Katarina Edwards; Fredrik Höök; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Antibiotics have made a tremendous contribution to mankind. They are one of the most successful medicines in human history. However, more and more bacterial strains develop resistance and the risk to public health can hardly be overstated. New types of antibiotics are urgently needed. LÄS MER

  7. 5. Protein-Surfactant Interactions in Complex Systems : Study of Physical Stability of Proteins and Peptides

    Författare :Johanna Hjalte; Avdelningen för livsmedel och läkemedel; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; therapeutic proteins; NMR nuclear magnetic resonance ; physical stability; surfactant protein interaction; preservative protein interaction; peptide aggregation;

    Sammanfattning : My objective has been to characterize protein-surfactant interactions in pharmaceutically relevant formulations. Thus, the behavior of selected excipients, proteins and peptides has been studied as the system in question is driven to the verge of instability in different manners; by inducing aggregation, by inducing surfactant complexation, or by inducing precipitation by increasing ionic strength in the presence of preservative. LÄS MER