Sökning: "allelic association"

Visar resultat 11 - 15 av 53 avhandlingar innehållade orden allelic association.

  1. 11. Computational and experimental approaches to regulatory genetic variation

    Författare :Malin Andersen; Jacob Odeberg; John Peden; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. LÄS MER

  3. 12. Functional genetics of the interleukin-4 receptors in allergic asthma

    Författare :Ann-Marie Bergin; Göteborgs universitet; []
    Nyckelord :Asthma; association study; candidate genes; IL4R; CIITA; alternative splicing; minigene;

    Sammanfattning : Asthma is a complex disorder, with both genetic and environmental factors contributing to disease development. Our aim was to analyse possible associations between genetic variations of immunologically important genes and the susceptibility to and severity of allergic asthma in adults. LÄS MER

  4. 13. Genetic association studies of symptoms, comorbidity and outcome in bipolar disorder and schizophrenia

    Författare :Dzana Sudic Hukic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia and bipolar disorder are complex brain disorders. Research has focused on applying brain research to understand the etiology, as well as clinical research to improve treatment, prognosis and progression. LÄS MER

  5. 14. Human leukocyte antigens with special reference to association and linkage in multiple sclerosis

    Författare :Anna Fogdell-Hahn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; MHC; multiple sclerosis; narcolepsy; lod score; linkage.;

    Sammanfattning : The polymorphism of HLA (human leukocyte antigen) is extensive. Allelic variation has previously been detected by cellular and serological methods. Today a variety of genomic typing techniques have been developed, which give higher resolution and a possibility to detect single nucleotide variations. LÄS MER

  7. 15. Molecular basis for the MHC class II association in rat experimental autoimmune encephalomyelitis

    Författare :Katrien L de Graaf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis investigates the functional and structural aspects of rat MHC class 11 molecules and studies their influence on MBP- and MOG-peptide induced experimental autoimmune encephalomylitis (EAE) in LEW MHC congenic rat strains. EAE is an animal model for multiple sclerosis (MS) and can be induced in rats with components of the myelin sheath . LÄS MER