Sökning: "allelic association"

Visar resultat 21 - 25 av 53 avhandlingar innehållade orden allelic association.

  1. 21. Muscles, Estrogen, and Bone

    Författare :Eva Ljunggren Ribom; Hans Mallmin; Karin Piehl-Aulin; Kim Thorsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Muscle strength; Bone mineral density; Ultrasound; Body composition; Hormone replacement therapy; Estrogen receptor alpha; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : Sweden has one of the highest incidences of osteoporotic fractures in the world. A more sedentary lifestyle is one of several proposed reasons for the increase in osteoporosis seen in the developed countries. LÄS MER

  3. 22. Molecular epidemiology of complex heritable disease : applications in genomics and metabolomics

    Författare :Robert Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Modern high-throughput molecular technologies (collectively referred to as “omic” platforms) are generating unprecedented amounts of data on human variation. The four papers in this thesis each investigate and characterize associations between common, complex, heritable disease, and genetic or metabolomic markers from omic platforms. LÄS MER

  4. 23. Mapping genetic diseases in northern Sweden

    Författare :Elisabet Einarsdottir; Dan Holmberg; Gösta Holmgren; Ulf Gyllensten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; isolated populations; linkage disequilibrium; linkage analysis; genome-wide scan; hereditary sensory and autonomic neuropathy; type 1 diabetes mellitus; type 2 diabetes mellitus; autoimmune thyroid disease; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : The population of northern Sweden has previously been shown to be well suited for the mapping of monogenic diseases. In this thesis we have tested the hypothesis that this population could also be used for efficient identification of risk genes for common diseases. LÄS MER

  5. 24. The MHC and the recognition of self and altered self in experimental and rheumatoid arthritis

    Författare :Sabrina Haag; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Major histocompatibility complex (MHC) is a highly polymorphic and gene-dense region on chromosome 6 in humans and 20 in the rat. Genes in the MHC are the major risk factor for the development of autoimmunity. LÄS MER

  7. 25. Different genetic pathways involved in colorectal cancer

    Författare :Sima Salahshor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is one of the three leading causes of cancer mortality worldwide with an incidence of approximately one million cases and a mortality of 500 000 annually. Identification of different pathways involved in tumorigenesis of both familial and sporadic colorectal cancer may led to a major breakthrough in the prevention of this potentially curable disease. LÄS MER