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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Adipose Tissue Heterogeneity - Development and Application of Nonlinear Microscopy Methods

    Författare :Alexandra Paul; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; least squares decomposition; stem cells; multivariate spectral analysis; obesity; adipose tissue; adipogenesis; broadband coherent anti-Stokes Raman scattering; extracellular matrix;

    Sammanfattning : Although the negative health impacts of obesity have been well documented, the number of overweight or obese patients has and is predicted to continue rising. One of the causal factors of obesity is a constant positive energy balance mainly from excessively high caloric intake from food compared with limited physical activity (caloric expenditure). LÄS MER

  3. 2. Who is Who in the Adipose Organ : A look at the Heterogeneity of Adipocyte Biology

    Författare :Jasper de Jong; Jan Nedergaard; Christian Wolfrum; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; Adipocyte; Brown; White; Brite Beige; Physiology; fysiologi; Physiology;

    Sammanfattning : The increasing prevalence of obesity and related health complications, such as type 2 diabetes, cardiovascular disease and cancer, demands thorough investigation of the underlying processes. One of the key tissues investigated in this context is adipose tissue. LÄS MER

  4. 3. Metabolic and endocrine function of human adipose tissue with focus on regional differences

    Författare :Vanessa van Harmelen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acylation stimulating protein; adipocytes; adipose tissue heterogeneity; adrenoceptors; insulin; leptin; lipogenesis; lipolysis; noradrenaline; plasminogen activator inhibitor-1; preadipocytes; tumour necrosis factor-cc;

    Sammanfattning : The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also has a secretory function. LÄS MER

  5. 4. Mitochondrial form and function in pancreatic β-cells and brown adipocytes

    Författare :Jakob D Wikström; Jan Nedergaard; Roberta Gottlieb; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondria; beta cells; brown adipose tissue; diabetes; obesity; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : This thesis is focused on the role of mitochondria in pancreatic β-cells and brown adipose tissue (BAT). Two main aspects of mitochondria were explored; mitochondrial functional efficiency and the interrelationship between mitochondrial shape and function. LÄS MER

  7. 5. The role of innate immunity in obesity-induced tissue inflammation

    Författare :Natalie Stiglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prevalence of obesity is rapidly increasing globally, which causes an increase in associated diseases such as type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). In addition to the detrimental effect of obesity on several organs such as the liver and adipose tissue, obesity also has a profound effect on the immune system. LÄS MER