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Visar resultat 21 - 25 av 85 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Drug resistance in acute myeloid leukemia : pharmacokinetic and in vitro studies

    Författare :Lars Möllgård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemotherapy has improved clinical outcome in adult acute myeloid leukemia (AML) but still the majority of the patients die of their disease. One important explanation is transport mediated drug resistance resulting in refractory or relapsing disease. P-glycoprotein (Pgp) is located in the membrane and can extrude cytostatic drugs. LÄS MER

  3. 22. Pharmacogenetic studies in childhood acute lymphoblastic leukaemia with primary focus on methotrexate

    Författare :Jannie Gregers; Curt Peterson; Birgitte Lausen; Kim Dalhoff; Martin Stanulla; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Childhood acute lymphoblastic leukaemia is the most common type of cancer in children. Improvement in treatment has increased survival to approximately 85 per cent. LÄS MER

  4. 23. Toxicity of metal containing micro- and nanoparticles : studies from an inhalation perspective

    Författare :Johanna Kain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Particles in urban environments have for a long time been associated with different health problems and diseases, such as worsening of asthma and chronic obstructive pulmonary disease as well as cancer and cardiovascular diseases. In addition, metal containing particles present in occupational settings and industries, particularly particles produced during welding, have been linked to several adverse health effects. LÄS MER

  5. 24. Acute myeloid leukemia : apoptotic signalling and gene expression associated with treatment response

    Författare :Marita Lagergren Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a severe, life threatening malignancy characterized by a clonal expansion of immature myeloid cells in the bone marrow, resulting in severe infections and bleedings. High dose chemotherapy is able to normalize the blood and bone marrow morphology (complete remission, CR) in a majority of treated patients, but recurrent disease, typically occurs within 1-2 years. LÄS MER

  7. 25. Inhibition of acute allogaft rejection - experimental transplant studies with biological and chemical immunosuppressants

    Författare :Zhongquan Qi; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; tacrolimus; MNA; leflunomide; cyclosporine; drug effects; graft survival; immunosuppression; heart; animal; transplantation; Immunologi; serologi; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : In clinical transplantation immunosuppressive agents are used in combination with the objective to achieve additive effects and less toxicity. A large number of novel drugs are candidates for clinical introduction at this time and experiments in animal models have an important role to play. LÄS MER