Sökning: "Tumor burden"

Visar resultat 1 - 5 av 80 avhandlingar innehållade orden Tumor burden.

  1. 1. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis

    Författare :Julia Femel; Anna-Karin Olsson; Grietje (Ingrid) Molema; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor; therapeutic; cancer vaccine; angiogenesis; vasculature; fibronectin; galectin-1; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. LÄS MER

  3. 2. Artificial Intelligence-based Assessment of Prostate Cancer Metastases in PET/CT

    Författare :Sarah Lindgren Belal; Malmö Nuklearmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artificial intelligence AI ; Convolutional neural networks CNN ; PET CT; Prostate cancer; Automated; Tumor burden; Bone metastases; Lymph node metastases;

    Sammanfattning : Background: Quantification of tumor burden from bone scan in the form of automated Bone Scan Index (aBSI) has been validated as an imaging biomarker for patients with prostate cancer. Positron emission tomography combined with computed tomography (PET/CT) is more sensitive and accurate compared to conventional imaging such as bone scan. LÄS MER

  4. 3. Somatic Genetic Variation in Children: from Mosaicism to Cancer

    Författare :Anders Valind; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic Mosaicism; Cancer; Tumor heterogeneity; Neuroblastoma; Wilms Tumor; Rhabdomyosarcoma; Aneuploidy;

    Sammanfattning : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. LÄS MER

  5. 4. Body constitution, statin use, and tumor characteristics. Implications for prognosis

    Författare :Helga Tryggvadottir; Epidemiologi och farmakogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; prognosis; tumor-specific markers; HMG-CoA reductase; aryl hydrocarbon receptor; aromatase; statins; anthropometric factors;

    Sammanfattning : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. LÄS MER

  7. 5. TGF-β Family Signaling in Tumor Angiogenesis

    Författare :Nikolas Eleftheriou; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. LÄS MER