Sökning: "T-cells"

Visar resultat 31 - 35 av 1144 avhandlingar innehållade ordet T-cells.

  1. 31. Functional studies of T-cells in rheumatoid arthritis

    Författare :Louise Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T-cells; Rheumatoid arthritis; inflammation; cytokines; collagen type II; immunomodulation;

    Sammanfattning : Rheumatoid arthritis (RA) is a systemic inflammatory disease with autoimmune features primarily affecting the joints. The etiology of RA is largely unknown but involvement of the immune system in the disease process is evident from the infiltration of leukocytes into the joint, and by the production of proinflammatory cytokines, chemokines and proteases, mainly by macrophages. LÄS MER

  3. 32. T cells in chronic obstructive pulmonary disease

    Författare :Ester Roos-Engstrand; Anders Blomberg; Anders Bucht; Annelie F Behndig; Magnus Sköld; Claes-Göran Löfdahl; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelium; bronchoscopy; bronchoalveolar lavage; endobronchial mucosal biopsies; inflammation; flow cytometry; T lymphocytes; CD25; CD127; FoxP3; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

    Sammanfattning : Background: Tobacco smoking is the main cause of chronic obstructive pulmonary disease, COPD, but the mechanisms by which cigarette smoke induces COPD are still elusive. T lymphocytes have been implicated in the pathogenesis of the disease, but their role in the airway inflammation in COPD is not fully understood. LÄS MER

  4. 33. T cells and costimulatory factors in myasthenia gravis

    Författare :Maria Kakoulidou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T cells; Myasthenia gravis MG ; costimulation; autoimmune disease; genetic polymorphism; twin;

    Sammanfattning : The autoimmune disease myasthenia gravis (MG) is characterized by muscle weakness due to a loss of acetylcholine receptors (AChR) at the neuromuscular end plate. Most MG patients have pathogenic antibodies directed against the receptor. We provide further evidence that T cells are important for establishment and continuation of the disease. LÄS MER

  5. 34. Regulatory T cells : molecular and clinical aspects

    Författare :Malin E Winerdal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the immune system’s tug of war with cancer, tolerance mechanisms by which the tumor can control anti-tumor immune responses play a central role in determining the outcome. Regulatory T cells (Treg) induced in the thymus or the periphery, represent one such tolerance mechanism that potentially can be exploited by developing tumors. LÄS MER

  7. 35. Redox regulation of T cells in autoimmunity

    Författare :Jaime Rose James; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the population which is mediated by both genetic and environmental risk factors. LÄS MER