Sökning: "Sara Ekelund"

Hittade 1 avhandling innehållade orden Sara Ekelund.

  1. 1. Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Ekelund; Sigurd Vitols; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; Cytotoxic drug development; Cytosensor microphysiometer; cellular metabolism; CHS 828; guanidino-containing compound; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : This thesis describes the use of a new technology, the Cytosensor® microphysiometer, in the in vitro evaluation of cytotoxic drugs, using the lymphoma cell line U-937 GTB and primary cultures of tumour cells from patients as model systems. The method was specifically applied to study the metabolic effects of the novel cyanoguanidine N-(6-(4-chlorophenoxy)hexyl)-N’-cyano-N’’-4-pyridylguanidine, CHS 828, currently in phase I/II clinical trials. LÄS MER